Merck Anti-Rad51 Antibody, clone 3C10
DNA 복구 단백질 RAD51을 인식하는 mouse monoclonal antibody. BRCA1/BRCA2 복합체와 상호작용하며 상동 재조합 연구에 활용. 다양한 조직에서 RAD51 발현 분석에 적합.
- 카탈로그번호
- 05-530-I-25UG
- 브랜드
- Merck Sigma
- 판매단위
- pk
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Anti-Rad51 Antibody, clone 3C10
Clone Information
- Clone: 3C10
- Host: Mouse
- Target: DNA repair protein RAD51 homolog 1 (HsRAD51, hRAD51, RAD51 homolog A, Rad51)
Description
DNA repair protein RAD51 homolog 1 (UniProt Q06609; also known as BRCA1/BRCA2-containing complex subunit 5, Homolog of E. coli RecA, hRAD51, HsRAD51, RAD51 homolog A, RecA-like protein, Recombination protein A) is encoded by the RAD51 gene (also known as HRAD51, HsT16930, BRCC5, MRMV2, RAD51A, RECA) in humans.
RAD51 is a member of the RecA family recombinases. It interacts with BRCA1 and BRCA2 to activate homologous recombination. RAD51 exhibits DNA-dependent ATPase activity and participates in double-strand break (DSB) repair by unwinding DNA to form a helical nucleoprotein filament.
It is highly expressed in the testis and thymus, while lower expression levels are found in the small intestine, placenta, colon, pancreas, and ovaries.
Specifications
| 항목 | 내용 |
|---|---|
| Clone | 3C10 |
| Host Species | Mouse |
| Target | RAD51 (DNA repair protein RAD51 homolog 1) |
| Gene ID | 5888 |
| UniProt ID | Q06609 |
| Alternative Names | BRCA1/BRCA2-containing complex subunit 5, hRAD51, HsRAD51, RAD51A, RecA-like protein |
| Function | DNA-dependent ATPase; homologous recombination; DSB repair |
| Expression | High in testis and thymus; lower in small intestine, placenta, colon, pancreas, ovaries |
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