Merck Anti-Nanog antibody, Mouse monoclonal

Anti-Nanog antibody, Mouse monoclonal

clone NNG-811, purified from hybridoma cell culture

Quality Level

200

생물학적 소스

mouse

결합

unconjugated

항체 형태

purified immunoglobulin

antibody product type

primary antibodies

클론

NNG-811, monoclonal

form

buffered aqueous solution

분자량

~40 kDa

species reactivity

human

포장

antibody small pack of 25 μL

농도

~2 mg/mL

technique(s)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: 4-8 μg/mL

동형

IgG1

UniProt 수납 번호

Q9H9S0

배송 상태

dry ice

저장 온도

−20°C

Gene Information

human ... NANOG(79923)

Nanog is a homeodomain transcription factor expressed in cells of the inner cell mass of early embryos, in embryonic stem cells (ESC), germ cells and in stem/progenitor cells of some tissues. Together with Oct-4, Sox-2, and Rex-1, it is a molecular marker for pluripotent cells and for undifferentiated stem cells. This protein is crucial for the maintenance of pluripotency of ESCs and is down-regulated when ESCs differentiate.
Nanog controls the expression of many ESC genes together with other stem cell transcription factors like Oct-4 and Sox-2. Nanog targets both repressor and activator complexes to regulatory regions of hundreds of genes in the genome. Expression of nanog can be detected primarily in germ cell tumors and in tumors of other cell types. Nanog is an important marker for Seminomas, testicular carcinomas, teratocarcinomas, and germ cell-like tumors in various tissues. Furthermore, it was shown to transform NIH3T3 cells.