Merck Anti-acetyl-p53 Antibody (Lys373, Lys382)

Anti-acetyl-p53 Antibody (Lys373, Lys382)

serum, Upstate®

생물학적 소스

rabbit

Quality Level

100

항체 형태

serum

antibody product type

primary antibodies

클론

polyclonal

species reactivity

vertebrates

포장

antibody small pack of 25 μL

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

동형

IgG

NCBI 수납 번호

NM_000546

UniProt 수납 번호

P04637

배송 상태

dry ice

p53 is a DNA-binding, oligomerization domain and transcription activation domain-containing tumor suppressor that upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation and cell cycle control mechanisms. p53 localizes to the nucleus yet can be chaperoned to the cytoplasm by the negative regulator MDM2, an E3 ubiquitin ligase that is upregulated in the presence of active p53, where MDM2 polyubiquitinates p53 for proteasome targeting. p53 can assemble into tetramers in the absence of DNA, fluctuates between latent and active (DNA-binding) conformations, and is differentially activated through posttranslational modifications including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) (amino acids 110-286) of p53 can compromise energetically favorable association with cis elements and are implicated in several human cancers.