Merck Anti-VEGF165 antibody, Mouse monoclonal
Mouse monoclonal Anti-VEGF165 항체로, 인간 VEGF-A 단백질을 인식합니다. 하이브리도마 세포 배양에서 정제되었으며 IgG1 동형입니다. 면역블롯팅에 적합하며, 암 및 혈관신생 연구에 유용합니다. -20°C에서 보관합니다.
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Anti-VEGF165 antibody, Mouse monoclonal
Clone
VG-20, purified from hybridoma cell culture
Synonyms
VEGF-A, Vascular permeability factor, Vascular endothelial growth factor A, VPF
제품 정보
| 항목 | 내용 |
|---|---|
| Biological source | Mouse |
| Antibody form | Purified from hybridoma cell culture |
| Antibody type | Primary antibody |
| Clone | VG-20, monoclonal |
| Species reactivity | Human |
| Packaging | 25 μL small pack |
| Concentration | ~1 mg/mL |
| Isotype | IgG1 |
| Technique(s) | Immunoblotting: 1–2 μg/mL using recombinant human VEGFA protein expressed in HEK-293 |
| UniProt accession no. | P15692 |
| Shipping conditions | Dry ice |
| Storage temperature | −20 °C |
Gene Information
Gene: human VEGF165 (7422)
VEGFA (Vascular Endothelial Growth Factor A), also known as Vascular Permeability Factor (VPF), is a major signaling growth factor belonging to the VEGF family, a subgroup of the Platelet-Derived Growth Factor (PDGF) proteins characterized by a conserved cystine-knot structure. VEGF expression is upregulated under hypoxia and in many types of cancers. VEGF receptors (VEGFR1 and VEGFR2) are often overexpressed in tumors, and high VEGF levels correlate with poor prognosis. Inhibition of VEGF-mediated angiogenesis pathways has potential in angiogenesis-related disease therapy, achievable by blocking circulating VEGF with antibodies such as Bevacizumab or Aflibercept, or by VEGFR-2 inhibition using small molecules like Gamabufotalin (CS-6) and Arenobufagin.
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