Merck Anti-VEGF165 antibody, Mouse monoclonal

Anti-VEGF165 antibody, Mouse monoclonal

clone VG-20, purified from hybridoma cell culture

VEGF-A, Vascular permeability factor, Vascular endothelial growth factor A, VPF

생물학적 소스

mouse

항체 형태

purified from hybridoma cell culture

antibody product type

primary antibodies

클론

VG-20, monoclonal

species reactivity

human

포장

antibody small pack of 25 μL

농도

~1 mg/mL

technique(s)

immunoblotting: 1-2 μg/mL using recombinant human VEGFA protein expressed in HEK-293

동형

IgG1

UniProt 수납 번호

P15692

배송 상태

dry ice

저장 온도

−20°C

Gene Information

human ... VEGF165(7422)

VEGFA - Vascular Endothelial Growth Factor A, also known as or Vascular permeability factor (VPF), is a major signaling growth factor member of the VEGF family, sub-group of the Platelet-Derived Growth Factor (PDFG) proteins, which is characterized by its conserved cystine-knot structure.1 VEGF expression is up regulated in hypoxia and in many types of cancers. Furthermore, VEGF receptors (VEGFR1 and VEGFR2) are also overexpressed in several tumors and studies have shown that high levels of VEGF correlates with poor prognosis.1-8 Inhibition of VEGF mediated angiogenesis signaling pathways have potential in angiogenesis-related disease therapy, this can be achieved by blocking either the circulating VEGF using Anti-VEGF antibodies such as Bevacizumab and Aflibercept5 or by VEGFR-2 inhibition using small molecules such as Gamabufotalin (CS-6) and Arenobufagin.6-8