Merck Anti-Connexin 43 antibody, Mouse monoclonal

Anti-Connexin 43 antibody, Mouse monoclonal

Clone CXN-6

Purified from hybridoma cell culture

Target Information

Connexin 43 (Cx43), also known as Gap junction alpha-1 protein or Gap junction 43 kDa heart protein, is a key component of gap junction channels that mediate cell-to-cell communication.

Product Description

Monoclonal Anti-Connexin 43 (mouse IgM isotype) is derived from the hybridoma CXN-6, produced by fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide from the C-terminal region of Connexin 43 protein conjugated to KLH.

Connexin 43 protein has:

• Four transmembrane domains (TMs)
• N- and C-terminal cytoplasmic tails oriented in the plasma membrane
• Two extracellular loop (EL) domains
• One cytoplasmic loop (CL)

Six connexin subunits assemble to form a connexon (hemichannel) in the plasma membrane. Docking of two hemichannels forms a gap junction channel enabling intercellular communication.

Cx43 is expressed in:

• Heart and brain tissues
• Melanocytes, keratinocytes, endothelial cells, and basal cells

It has been mapped to human chromosome 6q22.31.

Specifications