Merck Anti-Histone Deacetylase 1 (HDAC1) antibody produced in rabbit

Anti-Histone Deacetylase 1 (HDAC1) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

생물학적 소스

rabbit

Quality Level

200

결합

unconjugated

항체 형태

IgG fraction of antiserum

antibody product type

primary antibodies

클론

polyclonal

form

buffered aqueous solution

분자량

antigen 65 kDa

species reactivity

human, mouse

포장

antibody small pack of 25 μL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:500 using human lymph node sections
immunoprecipitation (IP): 5-10 μL using whole lysate of NIH3T3 cells
microarray: suitable
western blot: 1:20,000 using nuclear extract from HeLa human epithelioid carcinoma cells

UniProt 수납 번호

Q13547

배송 상태

dry ice

저장 온도

−20°C

Gene Information

human ... HDAC1(3065)
mouse ... Hdac1(433759)

Histone acetylation is a dynamic process whose levels are determined by the net activities of HATs and the competing enzymes histone deacetylases (HDACs). Both activities are associated with the nuclear matrix. Six or seven different mammalian HDACs have been described. HDAC1, HDAC2 and HDAC3 are similar to yeast Rpd3 protein, while HDAC4, HDAC5 and HDAC6 are similar to yeast Hda1 protein. Histone deacetylases activities were often, but not always, associated with transcriptional repression and nucleosomal condensations. HDAC1, HDAC2 and several other HDACs are the catalytic subunits of different multiprotein regulatory complexes.