Merck Anti-EZH2 Antibody

Anti-EZH2 Antibody

Upstate®, from rabbit

KMT6, Enx1, Enhancer of Zeste Homologue 2

생물학적 소스

rabbit

Quality Level

100

항체 형태

whole antiserum

antibody product type

primary antibodies

클론

polyclonal

species reactivity

human, mouse

포장

antibody small pack of 25 μL

manufacturer/tradename

Upstate®

technique(s)

ChIP: suitable (ChIP-seq)
immunoprecipitation (IP): suitable
western blot: suitable

NCBI 수납 번호

NM_004456.3
NM_152998.1

UniProt 수납 번호

Q15910

배송 상태

ambient

Gene Information

human ... EZH2(2146)

Polycomb protein group complexes are responsible for the regulation of hundreds of genes in mammals and insects. These proteins are responsible for the assembly and packaging of chromatin and for the induction of methylation on Histone H3. EZH2 (enhancer of zeste homologue 2) is a member of the polycomb group of proteins and is involved in cell cycle regulation. EZH2 represses transcription via trimethylation of histone H3 on Lys27 (H3K27) as indicated by the fact that RNAi-mediated knockdown of EZH2 resulted in a loss of H3K27 trimethylation. The expression of this protein in human tumors is aggressive for hormone refractory prostate cancer. In breast cancer EZH2 expression was increased in malignant tumors and promoted anchorage independent and invasive growth in vitro.