Merck Monoclonal Anti-Nitric Oxide Synthase, Inducible antibody produced in mouse

Monoclonal Anti-Nitric Oxide Synthase, Inducible (iNOS) Antibody

Clone NOS-IN, Ascites Fluid

Monoclonal Anti-Nitric Oxide Synthase, Inducible (iNOS) (mouse IgG1 isotype) is derived from the NOS-IN hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized BALB/c mouse.

Nitric oxide synthase (NOS) is classified into three types based on molecular mass, subcellular location, and Ca²⁺ dependence:

• Type I NOS (150–160 kDa): Found in neurons; also known as NOS-1, neuronal NOS (nNOS), brain NOS (bNOS), cerebral NOS, constitutive NOS, or Ca²⁺-regulated NOS (cNOS).
• Type II NOS (130 kDa): Best characterized in macrophages; also known as macrophage NOS (mNOS) or inducible NOS (iNOS).
• Type III NOS (135 kDa): Found in endothelial cells; also called endothelial NOS (eNOS or ecNOS).

Type II NOS (iNOS) is Ca²⁺-independent and is expressed in activated macrophages and some glial cells after stimulation. iNOS is also found in several other cell types, including hepatocytes, chondrocytes, endothelial cells, and fibroblasts.

제품 사양 (Specifications)