Merck Anti-GluR2 Antibody

Anti-GluR2 Antibody

from rabbit, purified by affinity chromatography

Glutamate receptor 2, GluR-2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, GluA2

생물학적 소스

rabbit

Quality Level

100

항체 형태

affinity isolated antibody

antibody product type

primary antibodies

클론

polyclonal

정제법

affinity chromatography

species reactivity

human, mouse, rat

포장

antibody small pack of 25 μg

technique(s)

immunohistochemistry: suitable (paraffin)
western blot: suitable

NCBI 수납 번호

NP_058957

UniProt 수납 번호

P19491

배송 상태

wet ice

Glutamate receptors (GluRs) can be categorized as ionotropic or metabotropic and subcatergorized by their agonist preferences (NMDA, AMPA or Kainic acid). There are four types of AMPA selective GluR subunits (GluR1, GluR2, GluR3 and GluR4). Tetrameric or pentameric combinations of different subunits contributes to the functional diversity of AMPA receptors. In general, AMPA receptors mediate fast synaptic current at most excitatory synapses, with stoichiometry characterized by subtype composition. Although subunit composition of AMPA receptors varies, they must contain at least one edited GluR2 subunit to be calcium impermeable. Relative calcium permeability in AMPA receptor channels may be significant in pathological neurotoxic damage and long term changes in nervous system responses.