Merck Anti-pan Ago Antibody, clone 2A8

Anti-pan Ago Antibody, clone 2A8

Clone Information

• Clone: 2A8
• Host: Mouse

Target Information

• Target: Eukaryotic translation initiation factor 2C (Argonaute family proteins)
• Recognized Proteins: Argonaute-2 (Ago2), Argonaute-4 (Ago4), Protein slicer, PAZ Piwi domain protein

Product Description

Argonaute (Ago) proteins are a family of approximately 95 kDa proteins that bind directly to mature miRNAs. In mammals, there are four Ago proteins (Ago1–4). These proteins form the core of mammalian miRNPs, mediating essential functions in small RNA-directed regulatory pathways.

The Ago family is divided into two subclasses—Ago and Piwi—each containing two characteristic domains: PAZ and PIWI.

• The PAZ domain interacts with the 3’-end of the miRNA.
• The PIWI domain interacts with the 5’-phosphate and 5’-proximal region of the miRNA to guide target mRNA recognition.

Specifications