Merck Anti-Polyglutamines antibody, Mouse monoclonal

Anti-Polyglutamines Antibody, Mouse Monoclonal

제품 개요

• Clone: 3B5H10
• Form: Purified from hybridoma cell culture
• Concentration: ~2 mg/mL
• Type: Primary antibody
• Specificity: Anti-Huntingtin (polyglutamine stretch)
• Source: Mouse monoclonal IgG1

제품 설명

Abnormal stretch of triplet CAG (or CAA) codon produces a homomeric repeat of glutamine residues beyond the critical threshold and will lead to neurodegenerative disease.
Monoclonal mouse anti-polyglutamine antibody can be used to detect poly Q protein expression and in western blot.
This antibody reacts specifically to homomeric polyglutamines independent of the species.

스펙 정보

적용 기술

• Immunocytochemistry: suitable
• Immunoprecipitation (IP): suitable
• Western blot: 1–2 μg/mL using extract of HEK-293T cells transfected with an N-terminal 171 amino acid fragment of human Huntingtin with a 68 glutamine stretch