Merck Kallikrein-3 human

Kallikrein-3 human

recombinant, expressed in HEK 293 cells, ≥92% (SDS-PAGE)

KLKB1, APS, Hk3, Seminin, KLK3, Semenogelase, PSA, KLK2A1

생물학적 소스

human

재조합

expressed in HEK 293 cells

태그

6-His tagged (C-terminus)

assay

≥92% (SDS-PAGE)

form

lyophilized

분자량

calculated mol wt 27.7 kDa
observed mol wt 36 kDa (DTT-reduced. Protein migrates due to glycosylation. Ala 18 is the predicted N-terminal.)

포장

pkg of 10 μg

UniProt 수납 번호

P03952

배송 상태

wet ice

저장 온도

−20°C

Gene Information

human ... KLK3(3818)

KLK3 (Kallikrein-3), or plasma kallikrein (PKK), is a serine protease which was first identified from Fletcher trait, a hereditary disorder characterized by an extended partial thromboplastin time which however becomes normal upon exposing of plasma to a clot-promoting surface. Kallikerin proteins are classified into two major groups, plasma kallikrein and tissue kallikreins. Human cDNA of KLK3 codes for a leader peptide of 19 residues and a 619-residue mature prekallikrein protein. The mature protein contains a 371-residue N-terminal heavy chain which is composed of four Apple domains, the homologues of which are also found in factor XI. Both the heavy and light chains are highly glycosylated, and the light chain can exist as 36- and 33-kDa isoforms due to variation in the carbohydrate moiety. KLK3 gene is localized to human chromosome 4q35. The encoded protein is synthesized in the liver as a proenzyme known as prekallikrein.