Merck Kallikrein-3 human

Kallikrein-3 human

Recombinant human Kallikrein-3 protein expressed in HEK 293 cells, purified to ≥92% (SDS-PAGE).

Synonyms: KLKB1, APS, Hk3, Seminin, KLK3, Semenogelase, PSA, KLK2A1

생물학적 소스

• Human

재조합 발현

• Expressed in HEK 293 cells

태그 정보

• 6-His tagged (C-terminus)

Assay

• ≥92% (SDS-PAGE)

형태

• Lyophilized

분자량

포장 단위

• 10 μg

UniProt 수납 번호

• P03952

배송 상태

• Wet ice

저장 온도

• −20°C

Gene Information

• Human: KLK3 (3818)

KLK3 (Kallikrein-3), also known as plasma kallikrein (PKK), is a serine protease initially identified in the Fletcher trait, a hereditary disorder characterized by extended partial thromboplastin time that normalizes upon plasma exposure to a clot-promoting surface.
Kallikrein proteins are divided into two major groups: plasma kallikrein and tissue kallikreins.
Human KLK3 cDNA encodes a leader peptide (19 residues) and a 619-residue mature prekallikrein protein. The mature protein contains a 371-residue N-terminal heavy chain composed of four Apple domains, similar to those found in factor XI. Both heavy and light chains are highly glycosylated, and the light chain exists as 36- and 33-kDa isoforms due to carbohydrate variation.
The KLK3 gene is localized to human chromosome 4q35, and the encoded protein is synthesized in the liver as a proenzyme known as prekallikrein.