Merck Fibroblast Activation Protein α human

Fibroblast Activation Protein α human

recombinant, expressed in _Sf_21 cells, ≥95% (SDS-PAGE)

Seprase, FAP

재조합

expressed in _Sf_21 cells

Quality Level

200

assay

≥1800 (pmoles/min/μg)
≥95% (SDS-PAGE)

form

solution

specific activity

≥1800 units/μg protein

불순물

≤1.0 EU/μg endotoxin

배송 상태

dry ice

저장 온도

−70°C

Fibroblast activation protein alpha (FAPa) is a type II transmembrane serine protease. It is present as a homodimeric integral protein with dipeptidyl peptidase IV like fold. It has an α/β-hydrolase domain and an eight-bladed β-propeller domain. It is not expressed in normal tissue. It is only expressed by activated fibroblast in response to pathologic situations. It is expressed in several pathogenic sites including cancer, fibrosis, arthritis, wounding, or inflammation.