Merck Proteinase 3 from human neutrophils

Proteinase 3 from human neutrophils

≥95% (SDS-PAGE)

Leukocyte proteinase 3, Neutrophil proteinase 4, P29, C-ANCA antigen, AGP7, Wegener autoantigen

생물학적 소스

human

assay

≥95% (SDS-PAGE)

form

frozen liquid

분자량

29 kDa

포장

pkg of 25 μg

UniProt 수납 번호

P24158

배송 상태

dry ice

저장 온도

−70°C

Gene Information

human ... AGP7(5657)

Proteinase 3 is one of the serine proteinases localized in azurophil granules of polymorphonuclear leukocytes. It has been identified as the autoantigen of Wegener granulomatosis, a systemic vasculitis complicated by melomonocyte proliferation. It exhibits proteolytic activity towards a range of substrates. It is physiologically inhibited by α1-antitrypsin. The protein has been described as having antibiotic and growth-promoting properties and causing emphysema when administered by tracheal insufflation. Proteinase 3 (PR-3) is also known as myeloblastin and p29b.