Merck SILuLite HAVCR1 Hepatitis A virus cellular receptor 1 human

SILu™Lite HAVCR1 Hepatitis A virus cellular receptor 1 human

recombinant, expressed in HEK 293 cells, MS Protein Standard

T-cell immunoglobulin mucin receptor 1 (TIM-1), T-cell immunoglobulin and mucin domain-containing protein 1 (TIMD-1), Kidney injury molecule 1 (KIM-1)

Quality Level

200

생물학적 소스

human

재조합

expressed in HEK 293 cells

태그

8-His tagged

assay

≥98% (SDS-PAGE)

form

lyophilized powder

효능

≥98% Heavy amino acids incorporation efficiency by MS

분자량

calculated mol wt 31 kDa

technique(s)

mass spectrometry (MS): suitable

적합성

suitable for mass spectrometry (internal calibrator)

UniProt 수납 번호

Q96D42

저장 온도

−20°C

Gene Information

human ... HAVCR1(26762)

HAVCR1 is a trans-membrane glycoprotein that is highly expressed in kidney proximal tubular cells with kidney injury. The KIM-1 ectodomain is cleaved, released into urine, and canbe quantified as a sensitive and specific biomarker for Acute Kidney Injury (AKI) in rodents and humans. In a recent study it was demonstrated that HAVCR1 is released into the circulation where it reports kidney injury in mice, rats, and humans with AKI and chronic kidney disease (CKD). Urinary HAVCR1 and MCP-1 levels, either alone or in combination, were significantly higher than those in AKI negative patients. Importantly, the combination of HAVCR1 and MCP-1 outperformed either biomarker alone.