Merck Human FGF-23 ELISA Kit

Human FGF-23 ELISA Kit

This Human FGF-23 ELISA Kit is used to measure & quantify FGF-23 levels in Metabolism & Inflammation & Immunology research.

Quality Level

100

species reactivity

human

assay range

sensitivity: 9.9 pg/mL
(minimum detectable concentrations in tissue culture/serum/plasma)
standard curve range: 9.9-2400 pg/mL
inter-assay cv: <11%
intra-assay cv: <11%

technique(s)

ELISA: suitable

detection method

colorimetric
fluorometric

Studies demonstrate that Fibroblast Growth Hormone-23 plays a critical role as a phosphate-regulating hormone. FGF-23 is responsible for the inhibition of renal tubular reabsorption of inorganic phosphorus and, consequently, the regulation of phosphorus homeostasis. FGF-23 mRNA is expressed in the brain, in the thymus at low levels, in dendritic cells, with the highest expression in osteocytes and osteoblasts during phases of active bone remodeling. Because circulating levels of FGF-23 are regulated by vitamin D and phosphorus, normal skeletal and soft tissue development require vitamin D and a functional vitamin D signaling pathway. Diseases resulting from aberrant FGF-23 expression include inherited forms of rickets, certain kidney diseases and phosphorus-related tumors.