Merck PF-06745268

PF-06745268

≥98% (HPLC)

2-[[(1aS,7bS)-1a,2-Dihydro-2,2-dimethyl-6-(trifluoromethyl)benzo[b]cyclopropa[d]pyran-7b(1H)-yl]methyl]-3,4-dihydro-7-(4-methyl-1H-imidazol-1-yl)-2H-pyrido[1,2-a]pyrazine-1,6-dione

assay

≥98% (HPLC)

form

powder

광학 활성

[α]/D -13 to -17°, c = 1.0 in methanol

manufacturer/tradename

Pfizer®

색상

white to beige

solubility

DMSO: 2 mg/mL, clear

주관자

Pfizer

저장 온도

2-8°C

SMILES string

O=C1C(N2C=C(N=C2)C)=CC=C3N1CCN(C[C@@]4(C5)[C@@]5([H])C(C)(C)OC6=C4C=C(C(F)(F)F)C=C6)C3=O

PF-06745268 is an orally available, brain penetrant, potent and selective γ-secretase modulator. PF-06745268 induces robust and sustained reduction of brain amyloid-β42 (Aβ42) in rats.