Merck UK-371,804 HCl

UK-371,804 HCl

≥98% (HPLC)

UK-371804 HCl, N-[[1-[(aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methyl-alanine hydrochloride, 2-(((4-Chloro-1-guanidino-7-isoquinolinyl)sulfonyl)amino)-isobutyric acid hydrochloride

Quality Level

100

assay

≥98% (HPLC)

form

powder

manufacturer/tradename

Pfizer®

색상

white to beige

solubility

DMSO: 10 mg/mL, clear (warmed)

주관자

Pfizer

배송 상태

dry ice

저장 온도

−20°C

SMILES string

CC(C)(NS(=O)(C1=CC2=C(C=C1)C(Cl)=CN=C2NC(N)=N)=O)C(O)=O.[H]Cl

UK-371,804 is a reversible, substrate-competitive, highly potent (Ki = 10 nM) and selective urokinase-type plasminogen activator (uPA) Inhibitor with excellent selectivity over tPA, plasmin, Factor IXa and Xa. When applied topically, UK-371,80 effectively penetrates into excisional wounds of experimental pigs with no adverse effect on wound closure. UK-371,804 effectively blocks EGR-FMK from binding human uPA even in the presence of tissue proteins.