Merck CP-31398 dihydrochloride hydrate

CP-31398 dihydrochloride hydrate

≥98% (HPLC)

N′-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine dihydrochloride hydrate

Quality Level

100

assay

≥98% (HPLC)

manufacturer/tradename

Pfizer®

저장 조건

desiccated

색상

yellow

solubility

H2O: ≥20 mg/mL

주관자

Pfizer

저장 온도

2-8°C

SMILES string

O.Cl.Cl.COc1ccc(cc1)\C=C\c2nc(NCCCN(C)C)c3ccccc3n2

InChI

1S/C22H26N4O.2ClH.H2O/c1-26(2)16-6-15-23-22-19-7-4-5-8-20(19)24-21(25-22)14-11-17-9-12-18(27-3)13-10-17;;;/h4-5,7-14H,6,15-16H2,1-3H3,(H,23,24,25);2*1H;1H2/b14-11+;;;

InChI key

JXIVIAMOMIONKY-UWCBQFGESA-N

Gene Information

human ... TP53(7157)
mouse ... TP53(22059)
rat ... TP53(24842)

CP-31398 dihydrochloride hydrate has been used as a p53 stabilizer:

• to evaluate its effects on the upregulation of miRNA in human neuroblastoma cells
• to study its effects on arsenic trioxide (ATO) stabilization of p53 folding
• to study its effects on regulation of miR-34 in PC12 cells