Merck PHA-665752 hydrate

PHA-665752 hydrate

≥98% (HPLC)

(3Z)-5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-3-[[3,5-dimethyl-4-[[(2R)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl]carbonyl]-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one hydrate

Quality Level

100

assay

≥98% (HPLC)

form

powder

광학 활성

[α]/D +50 to +70°, c = 0.2 in methanol

manufacturer/tradename

Pfizer®

색상

light yellow to light brown

solubility

DMSO: ≥20 mg/mL

주관자

Pfizer

저장 온도

2-8°C

SMILES string

O.Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)Cc4c(Cl)cccc4Cl)c(C)c1C(=O)N5CCC[C@@H]5CN6CCCC6

InChI

1S/C32H34Cl2N4O4S.H2O/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34;/h5,8-11,15-16,21,35H,3-4,6-7,12-14,17-18H2,1-2H3,(H,36,39);1H2/b24-16-;/t21-;/m1./s1

InChI key

MKHQWLQMOSOUEQ-SCLITUASSA-N

PHA-665752 hydrate has been used as a c-Met inhibitor:

• to study its effects on oxidative stress in human mammary epithelial MCF10A cells with extra centrosomes
• to study its effects on the clonogenicity of T-cell specific transcription factor/ lymphoid enhancer-binding factor-1 (TCF/LEF-1) responsive promoter to drive expression of green fluorescent protein (TOP-GFP) cancer stem cell (CSC) cultures
• to study its inhibitory effects on melanoma cell lines