Merck PF-06446846 hydrochloride

PF-06446846 hydrochloride

≥98% (HPLC)

N-(3-Chloropyridin-2-yl)-N-((3R)-piperidin-3-yl)-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide hydrochloride

assay

≥98% (HPLC)

form

powder

광학 활성

[α]/D -60 to -50°, c = 1 in methanol

manufacturer/tradename

Pfizer®

색상

white to beige

solubility

H2O: 2 mg/mL, clear

주관자

Pfizer

저장 온도

room temp

SMILES string

O=C(C1=CC=C(N2C(N=CC=C3)=C3N=N2)C=C1)N([C@H]4CNCCC4)C5=C(Cl)C=CC=N5

PF-06446846 is a selective orally active PCSK9 inhibitor that appears to act by causing the ribosome to stall when synthesizing PCSK9. PCSK9 binds to the LDL receptor, preventing it from removing LDL cholesterol from the blood. PF-06446846 was found to reduce plasma PCSK9 and total cholesterol levels in rats.