Merck Rapamycin

Rapamycin

Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus

23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine solution

Quality Level

300

생물학적 소스

Streptomyces hygroscopicus

vapor pressure

0.56 hPa ( 20 °C)

무균

0.2 μm filtered

assay

≥95% (HPLC)

form

solution

autoignition temp.

301 °C

농도

2.5 mg/mL in DMSO (2.74 mM)

색상

colorless to yellow

항생제 활성 스펙트럼

fungi
yeast

동작 모드

enzyme | inhibits

주관자

Pfizer

저장 온도

−20°C

Rapamycin is a macrocyclic triene antibiotic possessing potent immunosuppressant and anticancer activity. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. The effectors of mTOR action include 4EBP1 and S6K1.