Merck Streptozocin

Streptozocin

≥75% α-anomer basis, ≥98% (HPLC), powder

Streptozotocin, N-(Methylnitrosocarbamoyl)-α-D-glucosamine

Quality Level

200

assay

≥75% α-anomer basis
≥98% (HPLC)

form

powder

색상

white to light yellow

mp

121 °C (dec.) (lit.)

항생제 활성 스펙트럼

neoplastics

동작 모드

DNA synthesis | interferes

주관자

Pfizer

저장 온도

−20°C

SMILES string

CN(N=O)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O

InChI

1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1

InChI key

ZSJLQEPLLKMAKR-GKHCUFPYSA-N

Streptozocin or streptozotocin, is obtained from Streptomyces achromogenes. Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Streptozocin, a diabetagen, is especially toxic to pancreatic islet insulin-producing β-cells. It is toxic to GLUT2 positive neuroendocrine tumor cells.