Merck TP-472N

TP-472N

≥98% (HPLC)

1-[8-[2-(Cyclopropylmethoxy)phenyl]pyrrolo[1,2-a]pyrimidin-6-yl]-ethanone

Quality Level

100

assay

≥98% (HPLC)

form

powder

색상

white to beige

solubility

DMSO: 15 mg/mL, clear

저장 온도

2-8°C

SMILES string

O=C(C)C1=CC(C2=CC=CC=C2OCC3CC3)=C4N=CC=CN41

TP-472N is a negative control probe for TP-472. TP-472 is a selective probe for bromodomain-containing proteins BRD9 and BRD7. The BRD9/7 probe was developed out of a collaborative effort by Takeda and the SGC, and is of a different chemotype from BRD9/7 probes previously available. TP-472 has a KD value of 33nM for BRD9 and 340nM for BRD7 by ITC, is >30 fold selective for BRD9 over all other bromodomain family members except BRD7, and is suitable for in vivo applications. The negative control TP-472N is inactive against other bromodomains (>20μM against BRD9). For full characterization details of TP-472 and TP-472N, please visit the TP-472 probe summary on the Structural Genomics Consortium (SGC) website.

TP-472, the active BRD9/7 probe, is available from Sigma. To learn more about and purchase TP-472, click here.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc