상품 옵션 정보 | |||||||||
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카탈로그 번호 | CAS 번호 | 설명 | 상태 | 재고 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
SML1933-5MG | - | Merck SML1933-5MG TP-472N, 5 MG pk | 재고문의 | 0 | pk | 0원 | - | 0원 |
TP-472N
≥98% (HPLC)
1-[8-[2-(Cyclopropylmethoxy)phenyl]pyrrolo[1,2-a]pyrimidin-6-yl]-ethanone
Quality Level
assay
≥98% (HPLC)
form
powder
색상
white to beige
solubility
DMSO: 15 mg/mL, clear
저장 온도
2-8°C
SMILES string
O=C(C)C1=CC(C2=CC=CC=C2OCC3CC3)=C4N=CC=CN41
TP-472N is a negative control probe for TP-472. TP-472 is a selective probe for bromodomain-containing proteins BRD9 and BRD7. The BRD9/7 probe was developed out of a collaborative effort by Takeda and the SGC, and is of a different chemotype from BRD9/7 probes previously available. TP-472 has a KD value of 33nM for BRD9 and 340nM for BRD7 by ITC, is >30 fold selective for BRD9 over all other bromodomain family members except BRD7, and is suitable for in vivo applications. The negative control TP-472N is inactive against other bromodomains (>20μM against BRD9). For full characterization details of TP-472 and TP-472N, please visit the TP-472 probe summary on the Structural Genomics Consortium (SGC) website.
TP-472, the active BRD9/7 probe, is available from Sigma. To learn more about and purchase TP-472, click here.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
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