Merck Anti-Histone Deacetylase 8 (HDAC8) antibody produced in rabbit

Anti-Histone Deacetylase 8 (HDAC8) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

생물학적 소스

rabbit

Quality Level

200

결합

unconjugated

항체 형태

affinity isolated antibody

antibody product type

primary antibodies

클론

polyclonal

form

buffered aqueous solution

분자량

antigen ~43 kDa

species reactivity

human, mouse

향상된 검증

recombinant expression
Learn more about Antibody Enhanced Validation

technique(s)

immunocytochemistry: 1-2 μg/mL using cultured 293T cells expressing recombinant human HDAC8
immunoprecipitation (IP): 1-2 μg using extract of 293T cells expressing recombinant human HDAC8
western blot: 2-4 μg/mL using whole extract of human colon adenocarcinoma SW620 cells and a chemiluminescent detection reagent

UniProt 수납 번호

Q9BY41

배송 상태

dry ice

저장 온도

−20°C

Gene Information

human ... HDAC8(55869)
mouse ... Hdac8(70315)

Histone deacetylases (HDACs) are competing enzymes, belonging to histone deacetylase family. There are two classes of HDACs with six to seven different types of HDACs proteins. HDAC1,HDAC2, HDAC3, and HDAC8 belong to Class I HDACs and HDAC4, HDAC6, HDAC7, HDAC9, and HDAC10 belong to Class II HDACs. Class I HDACs consists of a single deacetylase domain at the N-termini and diversified C-terminal regions, while Class II contains a deacetylase domain at C-terminal position. Studies show that HDAC8 is a sex-linked gene located on the chromosome at position Xq21.2 - q21.3. HDAC8 gene has a molecular weight of 43kDa and it encodes a 377 amino acid protein. It is present within the nucleas. HDAC8 mRNA is seen in heart, lung, kidney, and pancreas.