Merck Anti-Fibroblast Growth Factor Receptor-2, Cytoplasmic antibody produced in rabbit

Anti-Fibroblast Growth Factor Receptor-2, Cytoplasmic antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

생물학적 소스

rabbit

Quality Level

200

결합

unconjugated

항체 형태

affinity isolated antibody

antibody product type

primary antibodies

클론

polyclonal

form

buffered aqueous solution

분자량

antigen 115-125 kDa (doublet)

species reactivity

human

향상된 검증

recombinant expression
Learn more about Antibody Enhanced Validation

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 2-4 μg/mL using trypsin-digested, human tissue sections
western blot: 0.25-0.5 μg/mL using extracts/lysates of FGFR-2 transfected cells

UniProt 수납 번호

P21802

배송 상태

dry ice

저장 온도

−20°C

Gene Information

human ... FGFR2(2263)

Fibroblast growth factors receptors (FGFRs) are members of the tyrosine kinase family of growth factor receptors. They are glycosylated 110-150 k Da proteins that are constructed of an extracellular ligand binding region with either two or typically three immunoglobulin (Ig)-like domains and an eight amino acid ′acidic box′, a transmembrane region and a cytoplasmic split tyrosine kinase domain that is activated following ligand binding and receptor dimerization. At the mRNA level, FGFR-2 is highly expressed in developing human tissues including the brain (preferentially in glial cells), choroid plexus, skin, lung, kidney and bone. It is widely expressed in many adult human and animal tissues. It may be found in several anchorage-dependent cells, such as normal and malignant breast cancer cells.