Merck Anti-BACE 1, N-Terminus (46-62) antibody produced in rabbit

Anti-BACE 1, N-Terminus (46-62) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

생물학적 소스

rabbit

Quality Level

200

결합

unconjugated

항체 형태

affinity isolated antibody

antibody product type

primary antibodies

클론

polyclonal

form

buffered aqueous solution

분자량

antigen 60-75 kDa

species reactivity

human

향상된 검증

recombinant expression
Learn more about Antibody Enhanced Validation

technique(s)

western blot: 1:1,000 using a whole cell extract from the human kidney HEK293 cell line stably transfected with human BACE-1

UniProt 수납 번호

P56817

배송 상태

dry ice

저장 온도

−20°C

Gene Information

human ... BACE1(23621)

The membrane-associated aspartic protease BACE-1 (β-site APP cleaving enzyme, Asp2 or memapsin 2) has been identified as β-secretase. BACE-1 constitutes the predominant β-secretase activity in human brain tissue. It is highly expressed in neurons, the major site of Aβ generation. BACE-1 is localized within the Golgi and endosomal compartments, among the several intracellular sites where Aβ is thought to be produced. BACE-1 is initially an inactive proenzyme and localized in endoplasmic reticulum.