Merck Pefabloc SC PLUS

Pefabloc® SC PLUS

solution, suitable for electrophoresis, solubility: 0.1 M in water, soluble, pkg of 2 × 25 mL (1 g)

PSC-protector, serine protease inhibitor

form

solution

Quality Level

100

분자량

239.5

포장

pkg of 2 × 25 mL (1 g)

manufacturer/tradename

Roche

농도

0.1-1.0 mg/mL

technique(s)

electrophoresis: suitable

mp

175-185 °C

solubility

water: soluble 0.1 M

배송 상태

wet ice

저장 온도

2-8°C

The Pefabloc® SC PLUS set combines the serine protease inhibitor Pefabloc® SC with a uniquely formulated Pefabloc® SC protector (PSC-Protector), adding additional convenience and reliability to the safe, stable protease inhibition provided by Pefabloc® SC .

Recent findings indicate that sulfonyl-type serine protease inhibitors such as Pefabloc® SC and PMSF can bind covalently to proteins. This can occur when the inhibitors are used in high concentrations, or during extended incubation times under alkaline conditions. This interaction adversely affects the tyrosine and lysine residues of a protein, as well as the free amino terminus. The PLUS additive (PSC-Protector) included with this set prevents covalent attachment of Pefabloc® SC to proteins when used in higher concentrations and extended incubation times at an alkaline pH.