Thermo Fisher Scientific Agrin Polyclonal Antibody
Agrin 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody로, WB 및 ICC/IF에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며, 고순도 affinity chromatography로 정제되어 있습니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human AGRN (Accession O00468), corresponding to amino acid residues V1978–P2028 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852921 |
Product Specific Information
Antibody detects endogenous levels of total AGRN.
Target Information
Agrin is a molecule located in the basal lamina of muscle cells and directs key events in postsynaptic differentiation. It plays a critical role in clustering acetylcholine receptors (AChRs) at the neuromuscular junction. Various agrin splice variants arise from alternative mRNA splicing, with forms containing inserts at the carboxy terminus (y and z) showing high affinity for AChRs. Muscle alpha-dystroglycan is proposed as the receptor for agrin’s clustering activity, though this remains debated. Tyrosine phosphorylation is an early required step in AChR aggregation, and the receptor tyrosine kinase MuSK interacts with agrin and localizes to developing muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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