Merck MultiScreen Permeability Filter Plate, 0.4 µm, non-sterile

MultiScreen Permeability Filter Plate, 0.4 µm, non-sterile

This 96-well filter plate has a Polycarbonate membrane used for Permeability studies.

material

flat bottom wells
polycarbonate membrane
polystyrene

Quality Level

400

무균

non-sterile

제품 라인

MultiScreen®

특징

lid

manufacturer/tradename

MultiScreen®

파라미터

100 μL sample volume (per well)

technique(s)

DNA purification: suitable
activity assay: suitable (with precipitations)
ligand binding assay: suitable
parallel artificial membrane permeation assay (PAMPA): suitable
receptor binding assay: suitable

플레이트 크기

96 wells

웰 최대 용적

300 μL

작업 용적

125 μL

공극 크기

0.4 μm pore size

application(s)

sample preparation

배송 상태

ambient

Increasing drug candidate predictability earlier in the discovery pipeline using non-cell-based assays can improve candidate throughput during the ADME stage. Non-cell-based permeability assays are predictive models for oral absorption of development candidates.

MultiScreen Permeability, MultiScreen-IP, and MultiScreen Acceptor plates support artificial membrane strategies for predicting passive transport.

Membranes have uniform pore structure and density for reliable transport:
- Individual wells minimize candidate cross-talk
- Compatibility with automated liquid handling systems increases throughput

Permeability Assay:
- The MultiScreen Permeability plate has a polycarbonate membrane, which supports a hexane/hexadecane artificial layer for permeability assays.1

PAMPA Assay:
- The MultiScreen-IP plate has a hydrophobic PVDF membrane, which supports a lipid bilayer for PAMPA asays.2,3

MultiScreen Acceptor Plate:
- The MultiScreen Acceptor plate can be used with either plate to capture passively transported compounds. Constructed of 100% PTFE, the plate can improve LC/MS results depending on the charge of the small molecules being evaluated.