Merck IFN-lambda 2 from mouse

IFN-lambda 2 from mouse

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

IL-28A

생물학적 소스

mouse

재조합

expressed in E. coli

assay

≥98% (HPLC)
≥98% (SDS-PAGE)

form

lyophilized

분자량

19.8 kDa

포장

pkg of 20 μg

technique(s)

cell culture | mammalian: suitable

불순물

<0.1 EU/μg endotoxin, tested

색상

white to off-white

UniProt 수납 번호

Q4VK74

배송 상태

wet ice

저장 온도

−20°C

Gene Information

mouse ... IL28A(338374)

IFN-λ 2 (Ifnl2) belongs to the type III interferon (IFN-λ) family of proteins. It is associated with antiviral, antitumor and immune activities. In a retinal autoimmunity mouse model, Ifnl2 increases the autoimmune disease. Ifnl2 signals via IFN (interferon)-λ receptor complex consisting of IL-10Rβ (interleukin 10 receptor β) and the IL-28Rα chains. The signaling pathway involves JAK1 (Janus kinase 1)/TYK2 (non-receptor tyrosine-protein kinase) tyrosine kinases, transcription factor complex IFN-stimulated gene factor 3 containing STAT1 (signal transducer and activator of transcription 1), STAT2 and IFN regulatory factor (IRF)-9.
Recombinant murine IFN-l2 is a 19.8kDa protein containing 175 amino acid residues.