Merck BAFF active human

BAFF active human

Animal-component free, recombinant, expressed in Nicotiana, >97% (SDS-PAGE)

TALL-1, Dendritic cell-derived TNF-like molecule, TNF- and APOL-related leukocyte expressed ligand 1, B lymphocyte stimulator, B-cell-activating factor BAFF, BLyS

Quality Level

200

생물학적 소스

human

재조합

expressed in Nicotiana

assay

>97% (SDS-PAGE)

form

lyophilized

효능

≤50 ng/mL ED50

분자량

18-20 kDa (a glycosilated polypeptide chain containing 151 amino acids)

포장

pkg of 10 μg

저장 조건

avoid repeated freeze/thaw cycles

불순물

Endotoxin, tested (LAL test, < 0.04 EU/ ug protein)

UniProt 수납 번호

Q9Y275

저장 온도

−20°C

Gene Information

human ... TNFSF13B(10673)

BAFF (B lymphocyte activating factor) is a member of the tumor necrosis factor (TNF) ligand family which is expressed in T Cells, macrophages, monocytes and dendritic cells. It is also known as BLyS, THANK, TALL, zTNF4 and TNFS20. BAFF enhances B cell survival in vitro and has emerged as a key regulator of peripheric B cell and it is vital homeostatic cytokine for B cells that helps regulate both innate and adaptive immune responses. BAFF binds to three TNF receptors: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium modulator and cyclophilin ligand interactor(TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF 13C).The human BAFF gene code for a 285 amino acids type II transmembrane protein. Recombinant human soluble BAFF is a 151 amino acids containing the TNF-like portion of the extracellular domain of BAFF.