Merck GDF-5 mouse

GDF-5 mouse

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

CDMP-1, BMP-14

생물학적 소스

mouse

재조합

expressed in E. coli

assay

≥98% (HPLC)
≥98% (SDS-PAGE)

form

lyophilized

효능

0.08-0.12 μg/mL

분자량

27.0 kDa

포장

pkg of 50 μg

불순물

<0.1 EU/μg endotoxin, tested

색상

white to off-white

UniProt 수납 번호

P43027

배송 상태

wet ice

저장 온도

−20°C

Gene Information

mouse ... GDF5(14563)

Mutations in the GDF-5 gene have been implicated in Grebe Syndrome, which is characterized by short stature, extra digits, short and deformed extremities, and in Hunter-Thompson type dwarfism. The mature and functional form of GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino-acid signal peptide and a 348 amino-acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease.