Merck IL-36 BETA human

IL-36 BETA human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

IL-1F8, IL-1H2, IL-1 eta

생물학적 소스

human

재조합

expressed in E. coli

assay

≥98% (HPLC)
≥98% (SDS-PAGE)

form

lyophilized

분자량

17.3 kDa

포장

pkg of 10 μg

불순물

<0.1 EU/μg endotoxin, tested

색상

white to off-white

UniProt 수납 번호

Q9NZH8

배송 상태

wet ice

저장 온도

−20°C

Gene Information

human ... IL36G(56300)

IL-36β is highly expressed in psoriatic plaques, and at lower levels in various other tissues. IL-36β signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36β also functions as an agonist of NF-kappaB, and stimulates the production of pro-inflammatory proteins, including IL-6, IL-8, BD-2, and BD-3.