Merck PEDF from mouse

PEDF from mouse

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Serpin F1, Stromal Cell-derived Factor 3, Pigment Epithelium-derived Factor, Caspin

생물학적 소스

mouse

재조합

expressed in E. coli

assay

≥95% (SDS-PAGE)

form

lyophilized

분자량

~470 kDa (Mouse PEDF aa 20-417 is fused at the C-terminus to a FLAG0174-tag.)

포장

pkg of 10 μg

불순물

<0.1 EU/μg endotoxin (LAL test)

UniProt 수납 번호

P97298

배송 상태

wet ice

저장 온도

−20°C

Gene Information

mouse ... Serpinf1(20317)

Pigment epithelium-derived factor (PEDF) is a 47 kDa secreted glycoprotein that belongs to the non-inhibitory serpin family group. PEDF is widely expressed in adult and fetal tissues, including brain, spinal cord, plasma, bone, prostate, pancreas, heart and lung. PEDF acts as an angiogenesis inhibitor with neurotrophic, immunomodulation and antitumor properties. It functions as anti-angiogenic agent by counterbalancing the proangiogenic effect of VEGF. PEDF is one of the most abundant proteins released by adipocytes and induces insulin resistance in adipocytes and human skeletal muscle cells. Recently, it has been reported that PEDF is sufficient to maintain the self-renewal of pluripotent human embryonic stem cells.