Merck Oncostatin M human

Oncostatin M human

OSM, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture

OSM

Quality Level

100

생물학적 소스

human

재조합

expressed in HEK 293 cells

assay

≥95% (SDS-PAGE)

form

lyophilized powder

효능

≤1 ng/mL EC50

품질

endotoxin tested

분자량

dimer 30 kDa (glycosylated)

포장

pkg of 5X10 μg
pkg of 10 μg

technique(s)

cell culture | mammalian: suitable

불순물

≤1 EU/μg

UniProt 수납 번호

P13725

저장 온도

−20°C

Gene Information

human ... OSM(5008)

Oncostatin M (OSM), LIF, G-CSF, IL-6, and CNTF are structurally related members of the same cytokine family sharing similarities in their primary amino acid sequences, predicted secondary structure, and receptor components. OSM is a growth-regulating cytokine, affecting a number of tumor and normal cells. This material was first identified by its ability to inhibit the growth of A375 melanoma cells and other human tumor cells, but not inhibit the growth of normal human fibroblasts. It acts synergistically with TGF β1 to inhibit the proliferation of tumor cells like A375 melanoma cells. It induces an increase in LDL receptor expression and LDL uptake by hepatoma cells. OSM activates synovial fibroblast-like cells to produce urokinase type plasminogen activator. OSM is secreted by macrophages and activated T lymphocytes.