
Merck Insulin-like Growth Factor-II human
재조합 인간 IGF-II 단백질로, 세포 배양용으로 적합합니다. ≥98% 순도와 낮은 엔도톡신 수준을 보장하며, 태아 성장과 발달 연구에 활용됩니다. IGF-I과 유사한 생물학적 활성을 가지며 −20°C에서 보관합니다.
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Insulin-like Growth Factor-II human
제품 개요
Recombinant human IGF-II, expressed in E. coli, lyophilized powder. Suitable for cell culture applications.
제품 설명
Insulin-like growth factor II (IGF-II), also known as multiplication stimulating activity (MSA), exhibits bioactivities nearly identical to IGF-I. IGF-II expression is highest in fetal tissues, playing a major role in growth and development. After birth, its expression decreases significantly but remains detectable in various tissues and some tumors. IGF-II interacts with IGF-II receptor (IGF-IIR), IGF-IR, and weakly with the insulin receptor (IR). In adults, IGF-II bioactivity is primarily mediated through IGF-IR, while during embryogenesis, IGF-IIR and IR may also contribute to normal growth.
제품 사양
| 항목 | 내용 |
|---|---|
| Quality Level | 200 |
| Biological Source | Human |
| Recombinant Expression System | E. coli |
| Assay | ≥98% (SDS-PAGE and HPLC) |
| Form | Lyophilized powder |
| Potency (ED50) | ≤2.0 ng/mL |
| Quality Test | Endotoxin tested |
| Molecular Weight | 7.5 kDa |
| Packaging | 5 × 50 μg, 50 μg |
| Application | Cell culture (mammalian, suitable) |
| Impurities | ≤0.1 EU/μg |
| UniProt Accession | P01344 |
| Storage Temperature | −20°C |
| Gene Information | Human IGF2 (3481) |
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