Merck R-SPONDIN-3 human

R-SPONDIN-3 human

recombinant, expressed in CHO cells, ≥95% (SDS-PAGE), ≥95% (HPLC)

Roof plate-specific spondin-3, RSPO3, PWTSR

생물학적 소스

human

재조합

expressed in CHO cells

assay

≥95% (HPLC)
≥95% (SDS-PAGE)

form

lyophilized

분자량

26.9 kDa

포장

pkg of 20 μg

불순물

endotoxin, tested

UniProt 수납 번호

Q9BXY4

배송 상태

wet ice

저장 온도

−20°C

Gene Information

human ... RSPO3(84870)

The R-Spondin (Rspo) proteins belong to the Rspo family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. The Rspo proteins can interact with the Frizzled/LRP6 receptor complex in a manner that causes the stabilization and resulting accumulation of the intracellular signaling protein, ?-catenin. This activity effectively activates and increases the subsequent nuclear signaling of ?-catenin. R-Spondin can also bind to the previously discovered G-protein coupled receptors, LGR-4 and LGR-5. Rspo/?-catenin signaling can act as an inducer of the transformed phenotype, and can also regulate the proliferation and differentiation of certain stem cell populations. Recombinant human R-Spondin-3 is a 26.9 kDa protein consisting of 240 amino acid residues. Due to glycosylation, R-Spondin-3 migrates at an apparent molecular weight of approximately 37.0 kDa by SDS PAGE analysis under reducing conditions.