Merck IGF-I Protein, Human Recombinant Animal Free

IGF-I Protein, Human Recombinant Animal Free

The Insulin-like growth factor I protein(or IGF-1 protein), also known as somatomedin C, is the dominant effector of growth hormone & is structurally homologous to proinsulin. Manufactured using all non-animal reagents.

IGF-1, IGF1, Insulinlike Growth Factor I, Insulinlike Growth Factor 1, Mechano growth factor, Somatomedin-C, IGFI

Quality Level

100

assay

>98% (SDS-PAGE and HPLC)

불순물

<0.1 μg/mg protein endotoxin (<1EU/μg)

NCBI 수납 번호

NM_000618.2

UniProt 수납 번호

P05019

배송 상태

dry ice

Insulinlike growth factor I, also known as somatomedin C, is the dominant effector of growth hormone and is structurally homologous to proinsulin. The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but, IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds.