Merck IL-4 human

IL-4 human

Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

BCGF, BCDF, B cell stimulating factor (BSF-1)

생물학적 소스

human

재조합

expressed in E. coli

assay

≥98% (HPLC)
≥98% (SDS-PAGE)

form

lyophilized

효능

≤0.2 ng/mL ED50

분자량

14.9 kDa

포장

pkg of 20 μg

technique(s)

cell culture | mammalian: suitable

불순물

<0.1 EU/μg endotoxin, tested

색상

off-white to yellow

UniProt 수납 번호

P05112

배송 상태

wet ice

저장 온도

−20°C

Gene Information

human ... IL4(3565)

IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant human IL-4 is a 14.9 kDa globular protein containing 129 amino acid residues.