Merck Heparin-Binding EGF-Like Growth Factor human

Heparin-Binding EGF-Like Growth Factor human

HB-EGF, recombinant, expressed in baculovirus infected _Sf_21 cells, lyophilized powder, suitable for cell culture

Heparin-Binding Epidermal Growth Factor-Like Growth Factor, HB-EGF, hHB-EGF

Quality Level

100

생물학적 소스

human

재조합

expressed in baculovirus infected _Sf_21 cells

assay

≥97% (SDS-PAGE and N-terminal analysis)

form

lyophilized powder

효능

≤3 ng/mL

품질

endotoxin tested

분자량

9.5 kDa

포장

pkg of 50 and 250 μg

저장 조건

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

UniProt 수납 번호

Q99075

저장 온도

−20°C

Gene Information

human ... HBEGF(1839) , HBEGF(1839)

Heparin-binding epidermal growth factor (HB-EGF), like BTC, is a heparin-binding EGF family member. Natural soluble HB-EGF is a 19 kDa glycoprotein of multiple forms due to heterogeneous truncations. Soluble HB-EGF is mitogenic and chemotactic for fibroblasts, keratinocytes, and smooth muscle cells but not capillary endothelial cells. Production of HB-EGF is detected in monocytes, macrophages, and vascular and aortic smooth muscle cells (SMC). HB-EGF may play a role in the pathogenesis of atherosclerosis. It may also be an effector of Jun-induced oncogenic transformation. HB-EGF binds to EGFR with high affinity and to ErbB with moderate affinity.