Merck IGF-I human

IGF-I human

Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

IGF-IA, Somatamedin C

생물학적 소스

human

재조합

expressed in E. coli

assay

≥98% (HPLC)
≥98% (SDS-PAGE)

form

lyophilized

효능

≤2.0 ng/mL ED50

분자량

7.6 kDa

포장

pkg of 100 μg

technique(s)

cell culture | mammalian: suitable

불순물

<0.1 EU/μg endotoxin, tested

색상

white to off-white

UniProt 수납 번호

P05019

배송 상태

wet ice

저장 온도

−20°C

Gene Information

human ... IGF1(3479)

IGFs (insulin like growth factors) are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-I expression is regulated by growth hormone. IGF-I signal through the tyrosine kinase type I receptor (IGF-IR). Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and three intra-molecular disulfide bonds.