Merck Human Collagen Type I

Human Collagen Type I

Quality Level

100

생물학적 소스

human

assay

>90% (collagen type I, SDS-PAGE)

form

liquid

manufacturer/tradename

Chemicon®

농도

1 mg/mL

technique(s)

cell culture | mammalian: suitable

불순물

<1% collagen type II,IV-VI & non-collagen proteins.
<10% collagen type III

input

sample type mesenchymal stem cell(s)
sample type induced pluripotent stem cell(s)
sample type neural stem cell(s)
sample type: human embryonic stem cell(s)
sample type epithelial cells
sample type pancreatic stem cell(s)
sample type hematopoietic stem cell(s)

solubility

water: soluble at 20 °C

NCBI 수납 번호

NM_000088.3

UniProt 수납 번호

P02452

배송 상태

dry ice

저장 온도

−20°C

Gene Information

human ... COL1A1(1277)

COL1A1 is the gene responsible for the production of the alpha1(I) chain of type I collagen. Collagen, which adds structure and strength to connective tissues, is found throughout the body for example, in skin, tendon, cartilage, ligaments, bone, the part of the eyeball that is white (sclera), and the spaces between cells and tissues called the extracellular matrix.

Type I collagen is initially produced as procollagen in cells. This protein consists of two pro-alpha1(I) protein strands combined with a pro-alpha2(I) procollagen strand that form a triple-stranded rope-like structure. While in the cell, enzymes modify certain amino acids in the protein (lysine and proline) by adding chemical groups that are necessary for the three strands to form stable molecules and make connections (cross-links) between chains. Other enzymes add sugars to the protein. Now complete, the triple-stranded type I procollagen molecule leaves the cell and is processed by enzymes that clip small segments off both ends. The procollagen molecules arrange themselves into long, thin fibrils outside of the cell. The fibrils come together in side-by-side groups to form collagen fibers. Cross-linking between molecules in fibrils produces a very stable protein structure, which contributes to collagen′s tissue strengthening function. {http://ghr.nlm.nih.gov}