Merck Complement C8 deficient serum human

Complement C8 deficient serum human

for complement assays

Quality Level

200

생물학적 소스

human

form

solution

기원

USA origin

technique(s)

activity assay: suitable

불순물

infectious agent, tested

UniProt 수납 번호

P07357

배송 상태

dry ice

저장 온도

−70°C

Gene Information

human ... C8A(731)

Complement C8 is one of the end terminals of the complement system contained in the membrane attack complex (MAC). A deficiency of C8 may result in an increased susceptibility to Neisseria meningitidis. The most common mutation resulting in a C8 deficiency is a C to T transition in exon 9 of the C8 beta gene. Recent research however, has also discovered that two separate heterogeneous mutations may result in C8 deficiency in patients displaying recurrent meningococcal meningitis. These mutations are a duplication mutation on exon 7 and a mutation on exon 3.