Merck Complement C7 from human serum

Complement C7 from human serum

≥85% (SDS-PAGE), ≥150,000 C7H50 units/mg protein

Quality Level

200

생물학적 소스

human serum

assay

≥85% (SDS-PAGE)

form

solution

specific activity

≥150,000 C7H50 units/mg protein

농도

1 mg/mL in 10 mM sodium phosphate, 150 mM sodium chloride, pH 7.2

technique(s)

activity assay: suitable

UniProt 수납 번호

P10643

배송 상태

dry ice

저장 온도

−70°C

Gene Information

human ... C7(730)

The complement system is a complex cascade involving proteolytic cleavage of serum glycoproteins often activated by cell receptors. This cascade ultimately results in induction of the inflammatory response, phagocyte chemotaxis and opsonization, and cell lysis.

A complex of complements C5b, C6, C7, and C8 mediates the polymerization of up to eighteen C9 molecules into a tube-like membrane attack complex that is inserted into the plasma membrane of unwanted organisms, such as of Gram-negative bacteria and viral infected cells. This channel through the lipid bilayer results in lysis of the cell.

Human Complement C7 is a β-2-globulin, which is composed of a single polypeptide chain. The initial binding of C7 and C6 to C5b is thought to form a stable complex for subsequent binding of C8 and C9. The resulting activated complex is responsible for membrane attack and lysis.