Merck 3dGRO Lung Organoid Maturation Medium

3dGRO™ Lung Organoid Maturation Medium

제품 개요

Serum-free, ready-to-use medium designed to differentiate lung bud organoids (LBOs) into mature branching lung organoids.

제품 설명

The lung epithelium undergoes a complex series of endoderm–mesoderm-mediated signaling events to generate a branched network of conducting airways (bronchi, bronchioles) and gas-exchanging units (alveoli). Differentiation stages include anterior/posterior and dorsal/ventral patterning, lung specification, lung budding, branching morphogenesis, and maturation.

The 3dGRO Lung Organoid Maturation Medium is a chemically defined, serum-free, ready-to-use medium used to differentiate LBOs into mature lung organoids that structurally resemble the in vivo branching airway and early alveolar structures. Large numbers of mature lung organoids can be generated expressing markers indicative of multiple lung and airway cell types, including:

• SFTPB and SFTPC
• MUC5AC
• EpCAM
• Sox9
• Nkx2.1
• Acetyl-α-tubulin
• Vimentin

Additionally, mature lung organoids express ACE2 and TMPRSS2, enabling their use in SARS-CoV-2 viral research.

구성 및 관련 제품

The 3dGRO Lung Organoid Maturation Medium is part of the 3dGRO Human Lung Organoid Culture System, which differentiates human iPS cells into mature lung organoids that mimic in vivo airway and alveolar architecture.

3dGRO Human Lung Organoid Culture System 구성품 (별도 판매):

• Definitive Endoderm Induction Medium (SCM302)
• Anterior Foregut Endoderm Induction Medium I (SCM305)
• Anterior Foregut Endoderm Induction Medium II (SCM306)
• 3dGRO™ Lung Organoid Branching Medium (SCM307)
• 3dGRO™ Lung Organoid Maturation Medium (SCM308)

추가 관련 제품:

• Human iPSC Derived AFE Progenitors (SCC301)

제품 스펙

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