Thermo Fisher Scientific SLUG Polyclonal Antibody
Thermo Fisher Scientific의 SLUG Polyclonal Antibody는 인간, 마우스, 토끼, 랫트에 반응하며 다양한 면역분석(WB, IHC, ICC/IF, ELISA)에 적합합니다. KLH 결합 합성 펩타이드(aa 5-120)를 면역원으로 사용하며, 고순도 Protein A 정제 및 안정적 액상 형태로 제공됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rabbit, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Slug, amino acids 5–120 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Slug is a member of the Snail family of C2H2-type zinc finger transcription factors, initially identified for its role in epithelial-mesenchymal transitions and neural tube formation during vertebrate embryogenesis. Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Upon expression, Slug binds E-box regions of promoters and represses transcription of genes like E-cadherin and Claudin-1. Its expression in breast, esophageal, and colorectal carcinomas correlates with poor prognosis. Additionally, Slug protects hemopoietic progenitor cells from radiation-induced apoptosis by repressing p53-mediated transcription of Puma, a BH3-only antagonist of Bcl-2 family members.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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