Thermo Fisher Scientific GPRC6A Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:1,000
• Immunocytochemistry (ICC/IF): 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total GPRC6A.

Target Information

GPRC6A is an Orphan-U GPCR with an unknown ligand.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist.
All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms.
An array of activating ligands participate in GPCR conformational changes leading to signaling via G-proteins and downstream effectors.
Ongoing studies have shown the complex reactions involved in negative regulation of GPCRs, which influence cellular physiological actions and drive pharmacological research for new drug candidates.
Notable GPCR-targeted pharmaceuticals include Zyprexa (Eli Lilly) and Claritin (Schering-Plough), major drugs in mental health and allergy markets.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.