Thermo Fisher Scientific GPRC6A Polyclonal Antibody
Human GPRC6A 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 사용 가능. 합성 펩타이드 면역원으로 제작되었으며, 액상 형태로 1 mg/mL 농도. PBS/glycerol buffer에 보존되며 -20°C에서 보관.
- 판매단위
- pk
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Applications
- Western Blot (WB): 1:500–1:1,000
- Immunocytochemistry (ICC/IF): 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GPRC6A (Accession Q5T6X5), corresponding to amino acid residues P504–T554 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851522 |
Product Specific Information
Antibody detects endogenous levels of total GPRC6A.
Target Information
GPRC6A is an Orphan-U GPCR with an unknown ligand.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist.
All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms.
An array of activating ligands participate in GPCR conformational changes leading to signaling via G-proteins and downstream effectors.
Ongoing studies have shown the complex reactions involved in negative regulation of GPCRs, which influence cellular physiological actions and drive pharmacological research for new drug candidates.
Notable GPCR-targeted pharmaceuticals include Zyprexa (Eli Lilly) and Claritin (Schering-Plough), major drugs in mental health and allergy markets.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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