Thermo Fisher Scientific PBX1 Monoclonal Antibody (3F7)
PBX1 단백질을 인식하는 Thermo Fisher Scientific의 단일클론 항체. Western Blot 및 ELISA에 사용 가능. Human 반응성, Mouse IgG2a 아이소타입. Affinity chromatography로 정제된 액상 항체로, -20°C에서 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.3 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3F7 |
| Immunogen | PBX1 (NP_002576, 213–321 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MQLKQSTCEA VMILRSRFLD ARRKRRNFNK QATEILNEYF YSHLSNPYPS EEAKEELAKK CGITVSQVSN WFGNKRIRYK KNIGKFQEEA NIYAAKTAVT ATNVSAHGS
Target Information
This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis and is required for skeletal patterning and programming.
A chromosomal translocation, t(1;19), involving this gene and the TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by that of this protein, constitutively activates transcription of genes regulated by the PBX protein family.
Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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