Thermo Fisher Scientific Cullin 9 Polyclonal Antibody

Applications

Tested Application and Dilution

• Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:50

Product Specifications

Product Specific Information

Immunogen sequence:
REGGIYAVLV CMQEYKTSVL VQQAGLAALK MLAVASSSEI PTFVTGRDSI HSLFDAQMTR EIFASIDSAT RPGSESLLLT VPAAVILMLN TEGCSSAARN GLLLLNLLLC NHHTLGDQII TQELRDTLFR HSGIAPRTEP MP

Highest antigen sequence identity to orthologs:

• Mouse: 89%
• Rat: 92%

Target Information

The continued localization of p53 to the nucleus is essential for its function as a tumor suppressor. PARC, a large Parkin-like ubiquitin ligase, has been identified as a cytoplasmic anchor protein in p53-associated protein complexes.
In the absence of stress, PARC inactivation results in nuclear localization of p53 and activation of p53-dependent apoptosis, while overexpression of this protein promotes cytoplasmic sequestration of p53.
PARC knockout mice were viable and exhibited no obvious phenotype, suggesting that other proteins, such as the highly related cullin family of E3 ubiquitin ligases, may perform similar functions in the absence of PARC.
It has also been suggested that p53 binding to PARC may serve to control PARC function.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.