Thermo Fisher Scientific Cullin 9 Polyclonal Antibody
Human Cullin 9 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 1:20–1:50 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS(40% glycerol) 용액 형태로 제공. p53 관련 단백질 복합체 연구에 활용 가능.
- 판매단위
- pk
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Applications
Tested Application and Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Cullin 9. Recombinant protein control fragment: Product #RP-91066 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2640253 |
Product Specific Information
Immunogen sequence:
REGGIYAVLV CMQEYKTSVL VQQAGLAALK MLAVASSSEI PTFVTGRDSI HSLFDAQMTR EIFASIDSAT RPGSESLLLT VPAAVILMLN TEGCSSAARN GLLLLNLLLC NHHTLGDQII TQELRDTLFR HSGIAPRTEP MP
Highest antigen sequence identity to orthologs:
- Mouse: 89%
- Rat: 92%
Target Information
The continued localization of p53 to the nucleus is essential for its function as a tumor suppressor. PARC, a large Parkin-like ubiquitin ligase, has been identified as a cytoplasmic anchor protein in p53-associated protein complexes.
In the absence of stress, PARC inactivation results in nuclear localization of p53 and activation of p53-dependent apoptosis, while overexpression of this protein promotes cytoplasmic sequestration of p53.
PARC knockout mice were viable and exhibited no obvious phenotype, suggesting that other proteins, such as the highly related cullin family of E3 ubiquitin ligases, may perform similar functions in the absence of PARC.
It has also been suggested that p53 binding to PARC may serve to control PARC function.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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